UA Dr. Robert Legenstein, WiMAus Prashant Joshi, M.S.
Institute for Theoretical Computer Science
Technische Universität Graz
A-8010 Graz, Austria
In this exercise, you are going to analyze an important electrophysiological feature of neurons; the post-inhibitory rebound also called as the post hyperpolarising response. For this exercise you are going to use the NEURON simulator.
The code sthA.hoc availaible at:
creates the soma for a subthalamic nucleus neuron. The code by default
only contains the default Hodgkin and Huxley types of sodium and potassium ion
selective channels, and the passive membrane properties. We would like to make
our neuron much more electrophysiologically characteristic of subthalamic nucleus
neurons. There are many channel types we would want to add, but for this exercise
we will add only one new type, i.e. the T-type calcium channel.
Sadly this cannot be done with the programming language hoc that we have used
to create the initial subthlamic neuron in sthA.hoc. Instead we have to learn
the Model Description Language (NMODL) provided for defining additional
distributed membrane mechanisms such as ion channels and calcium pumps and
point processes such as synapses.
The URL, http://web.mit.edu/neuron_v5.6/nrntuthtml/tutorial/tutD.html
gives a tutorial that shows you how to use NMODL to create the
T-type calcium channel that we intend to add to our model neuron. Follow this
tutorial and create the T-type calcium channel, and add it as an additional
membrane mechanism to your existing neuron model.
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